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Hydroxychloroquine

Hydroxychloroquine is a common name from a brand Plaquenil. It is a popular medication used to the treatment of malaria where malaria remains sensitive to chloroquine.

It is now researched to treat Covid 19 Coronavirus but the clear findings are unclear.

Why Hydroxychloroquine

Hydroxychloroquine is to prevent and curetheoutbreaks of malaria. It can also be used to treat discoid lupus erythematosus (DLE; a skin condition) or systemic lupus erythematosus (SLE; a full body condition) and rheumatoid arthritis symptoms (clears its symptoms not the disorder). Hydroxychloroquine is a class of drugs called antimalarial. It functions by blocking the bacteria causing malaria.

Recently why Hydroxychloroquine is so popular?

Currently, Hydroxychloroquine is being studied for the purpose of coronavirus disease 2019 (COVID-19) treatment. There is no such proof or evidence behind the treatment but it surely helps to cure from this virus. 2020 have seen massive explosion of this particular virus all around the globe and no one has its best treatment except Hydroxychloroquine.

Particularly, Hydroxychloroquine is an anti-malarial medicine which has seen beneficial for COVID-19 Virus. There is only limited information regarding its clinical trials.

Notably, the FDA (Food and Drug Administration) has approved an Emergency Use Authorization (EUA) to allow hydroxychloroquine to treat adults and adolescents who are suffering from COVID-19, but only after noticing once health. It should be strictly taken under medical surveillance whether it is for malaria or COVID-19.

How Hydroxychloroquine works?

Hydroxychloroquine upsurges lysosomal pH level in antigen-presenting cells. In some sensitive cases, it blocks toll-like receptors on plasmacytoid dendritic cells (PDCs). Toll-like receptor 9 (TLR 9), which distinguishesDNA-containing immune facilities, constructs interferon and roots the dendritic cells to develop and makes available antigen to T cells. Hydroxychloroquine, by lessening TLR signalling, stops the initiation of dendritic cells and the inflammatory practice.

The study in 2003 was conducted wherein this tablet obstructs the stimulation of the toll-like receptor (TLR) 9 family receptors. Toll-like receptors 9 are cellular receptors for contagious products that persuade inflammatory reactions through stimulation of the inborn immune system. Just like other anti-malarial medicine, even this medicine also doesn’t have a fully working process clear. Many have some assumptions that it comprises the inhibition of hemozoin biocrystallization, which simplifies the accumulation of cytotoxic heme.

Hydroxychloroquine can also treat systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever, and all types of malaria.Most commonly it is used for the purpose of primary Sjögren syndrome, post-Lyme arthritis and porphyria cutanea tarda.

Ensure, you talk to your doctor first and take this medicine under the complete medical observation. There are high possible chances of getting its risks by using this by your own. Even if it is prescribed for other use, confirm it from your personal healthcare practitioner.

How can we take Hydroxychloroquine?

Hydroxychloroquine tablet should be taken once in a week orally. This is particularly for adult or adolescent one dose the same day of each week. For prevention, one must take 1 or 2 week before you travel the malaria spotted areas then continue for 4 week once you return.

Swallow the tablets as a whole; do not split, chew, or crush them.

You can take it with a glass of milk or a meal.

Follow the instructions on your prescription label carefully, and ask your physician or pharmacist to clarify any part you do not understand. Do not increase or decrease the dose by yourself.

If you are taking hydroxychloroquine for symptoms like rheumatoid arthritis, it must get vanishes by 6 months. If it gets worsen then stop using it and call immediately to your doctor.

Does Hydroxychloroquine contradict with other medicine?

The person who is hypersensitivity to 4-aminoquinoline compounds should not take this medicine. Even doctors won’t prescribe this medicine for them.

Children are taken special care if they have given this particular medicine. It can be especially sensitive to an overdose, so it’s best to keep out of the reach of children.

Doctor’s keep track by using electrocardiograms (EKG), a test monitor to check your heart rate and rhythm since it does response to hydroxychloroquine.

If you are on high dose or kept for longer period of time, will recommend frequent eye exams. Since, hydroxychloroquine cause serious eye problems commonly. If you experience any eye issue, stop using hydroxychloroquine and call your doctor immediately.

Do not let anyone else take your medication by themselves. It may cause serious to them.

Does Hydroxychloroquine have any side effects?

Hydroxychloroquine may surely mild or severe sort of side effects. Inform your doctor if any of these symptoms are severe or do not go away:Headache, dizziness, loss of appetite, nausea, diarrhoea, stomach pain, vomiting, rash.

If you experience any of the following symptoms like difficulty reading or seeing, sensitivity to light, blurred vision, changes in vision, seeing light flashes or streaks, unusual bleeding or bruising, bleaching or loss of hair, mood or mental changes, irregular heartbeat, drowsiness, convulsions, decreased consciousness or loss of consciousness, thinking about harming or killing yourself then please call your doctor immediately.

Is it a habit forming medicine?

It can’t be habit forming medication until and unless one doesn’t have it in a wrong way. Doctor’s doesn’t prescribe this medicine for any other normal health issues which should be taken for a longer period of time. It’s a simple treatment of a week or two. Therefore, there won’t be assumptions regarding being it as a habit forming medicine.

What will happen if it is over-dosed?

If there is any over dosage, you will have to find the symptom and inform your doctor immediately or must any nearest healthcare centre. It may occur immediately after having a high dose of this medicine. The severe symptoms might be sleepiness, vision changes, seizures, stopping of breathing, and heart problems such as ventricular fibrillation and low blood pressure. Loss of vision may be permanent. Low blood potassium, to levels of 1 to 2 mmol/L, may also occur.

Particularly, Chloroquine has the high change of getting death cause due to the overdose since it has 20% heath cause. Where as hydroxychloroquine is predictable two to three times less hazardous. Periodically there is no such evidence regarding Hydroxychloroquine about death cause except leaving 3 deaths out of 8 cases.

On such cases, the treatment recommends early mechanical ventilation, cardiac monitoring, and activated charcoal. Intravenous fluids and vasopressors may require with epinephrine being the vasopressor of choice. Dialysis has not been found to be useful.

Mild Symptoms of overdose are Headache, drowsiness, visual disturbances, convulsions, irregular heartbeat

What are its interactions?

Interaction can cause too many other health problems thus to stop those particular health issue you must inform your doctor about

If you are allergic to hydroxychloroquine, chloroquine, primaquine, quinine, or any other drugs.

If you are having any prescription and non-prescription drugs, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention acetaminophen (Tylenol, others); azithromycin (Zithromax); cimetidine (Tagamet); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin), insulin and oral medication for diabetes; medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenytoin (Dilantin, Phenytek), or valproic acid (Depakene); amiodarone (Pacerone); methotrexate (Trexall, Xatmep); moxifloxacin (Avelox); praziquantel (Biltricide); and tamoxifen (Nolvadex).

if you are taking any antacids, you are eligible to take before or after 4 hours of hydroxychloroquine treatment.

If you are taking ampicillin, take it at least 2 hours later hydroxychloroquine.

if you have or have ever had liver disease, heart disease, a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), an irregular heartbeat, a low level of magnesium or potassium in your blood, psoriasis, porphyria or other blood disorders, G-6-PD deficiency (an inherited blood disease), dermatitis (skin inflammations), seizures, vision problems, diabetes, kidney problems, or if you drink large amounts of alcohol.

If you have ever had color blindness

if you are pregnant, planning to do so, or breast-feeding.

Are you aware of Hydroxychloroquine history?

In 1955, USA gave approval for Hydroxychloroquine for the medical use. Later, WHO like other organisation gave the permission and thus now it’s one of the safest and most effectual therapeutically treatment most required in the health system.

All over the world, the need for this medication was known. But now in 2020, it became the essential part of our lifestyle that’s only due to the coronavirus which neither treated or nor prevented by anyone. Only Hydroxychloroquine can help people who suffering from that particular virus.

As per the world health organization’s list of essential medicine, it has a huge capacity to treat many of the other disease which is yet to be finding out.

How can one purchase Hydroxychloroquine?

Hydroxychloroquine is easily available in the market but one thing is clear without prescription no one will allow to take. Therefore, its compulsion to take a prescription from your doctor or any healthcare practitioner before making any purchase of Hydroxychloroquine.

It’s very simple either buy it from online pharmacies or physical medical store. In every pharmaceutical store, you will get this sort of medicament. In recent times, the demand for Hydroxychloroquine is more and so its supply is also sufficient due to COIVD-19.

Doctor’s will prescribe you the first lower dose and later the standard dosage of this pill. There are many sites that makes this medicine easily available but ensure you choose for better one. The safety as well as accurate treatment will make you stand positive mentally and negative for COVID-19 like such disorder.

Other requirements

Store Hydroxychloroquine at room temperature of 20° and 25° C.

Keep Hydroxychloroquine and also other medicines away from children.

Additional news

There is very few evidence regarding the treatment of COVID 19, but the use of Hydroxychloroquine has make the treatment possible. This is until now a satisfactory concept for all of us. Until now, it haven’t harmed any one of us. So no worry. Doctors are doing their work and we just have to appreciate it. Stay calm and stay safe at home. As of 22 April 2020, there is limited evidence to support the use of hydroxychloroquine. While its use is not accepted by the FDA for COVID-19 as of 7 April 2020. In an Emergency Use Authorization, it have given temporary permission using it as an off-label treatment. In fact, the FDA has posted a caution against using this drug for COVID-19 “outsides the hospital premises or a clinical trial”.